The intracellular targets of motion of metronidazole on anaerobes are largely unknown. The five-nitro team of metronidazole is lowered by metabolically Lively anaerobes, and research have shown which the reduced type of the drug interacts with bacterial DNA.
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Siga atentamente las instrucciones que se encuentran en la etiqueta de la receta médica y pida al médico o farmacéutico que le explique cualquier parte que no comprenda. Utilice metronidazol exactamente como se le indica. No use una cantidad mayor ni menor del medicamento, ni lo use con más frecuencia de la que el médico le recete.
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Usage of cimetidine with oral metronidazole may prolong the fifty percent-lifetime and reduce plasma clearance of metronidazole.
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Metronidazole has shown evidence of mutagenic exercise in many in vitro bacterial assay methods. Also, a dose-response increase in the frequency of micronuclei was observed in mice just after intraperitoneal injections and an increase in chromosome aberrations are reported in clients with Crohn's disease who have been addressed with 200-1200 mg/day of metronidazole for one to 24 months.
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